Antibodies from Inflamed Central Nervous System Tissue Recognize Myelin Oligodendrocyte Glycoprotein
نویسندگان
چکیده
منابع مشابه
Oligodendrocyte Glycoprotein System Tissue Recognize Myelin Antibodies from Inflamed Central Nervous
متن کامل
Myelin-Oligodendrocyte Glycoprotein Antibodies Spectrum Disorders
Myelin-Oligodendrocyte Glycoprotein (MOG) is an adhesive molecule responsible for myelin sheath structural integrity and maintenance. Patients with spectrum of inflammatory demyelinating disease particularly in central nervous system are reported to have antibodies against this protein. Diseases such as multiple sclerosis, clinically isolated syndrome, neuro-myelitis optica (NMO) spectrum disor...
متن کاملMyelin oligodendrocyte glycoprotein has a dual role in T cell autoimmunity against central nervous system myelin
BACKGROUND Myelin oligodendrocyte glycoprotein (MOG) is a candidate primary target of the autoimmune attack on the central nervous system (CNS) in multiple sclerosis (MS). However, the physiological function of MOG has been unclear for a long time. OBJECTIVE We propose that MOG has a central role in the regulation of tolerance and autoimmunity. CONCLUSION The interaction of MOG with DC-SIGN...
متن کاملPathogenic myelin oligodendrocyte glycoprotein antibodies recognize glycosylated epitopes and perturb oligodendrocyte physiology.
Antibodies to myelin components are routinely detected in multiple sclerosis patients. However, their presence in some control subjects has made it difficult to determine their contribution to disease pathogenesis. Immunization of C57BL/6 mice with either rat or human myelin oligodendrocyte glycoprotein (MOG) leads to experimental autoimmune encephalomyelitis (EAE) and comparable titers of anti...
متن کاملElevated intrathecal myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis.
OBJECTIVE To evaluate antibodies to myelin oligodendrocyte glycoprotein (MOG) in the serum and cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS) and control individuals. DESIGN Prospective case-control series. SETTING Academic referral center. PATIENTS Twenty-six controls with noninflammatory neurologic disease and 35 patients with MS donated serum and CSF for recombinant...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2005
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.175.3.1974